Property Report: BRCA1

E	Experimentally determined
S	Predicted by sequence similarity
P	Predicted by analysis other than seq. similarity
K	Predicted by BioKnowledge^TM Transfer by BIOBASE
see	Indicates references that mention and cite a finding, but do not demonstrate it directly.

Human BRCA1	BRCA1

Gene/Protein	Molecule	Alteration	Relationship	Sub-type / Linked disorders	Biological Process	Disease	Tissue Specificity	Annotation & Reference
BRCA1	DNA	gene mutation	may cause		chromatin remodeling	Breast Neoplasms		mutation in the BRCA1 gene may cause abnormal chromatin remodeling associated with breast neoplasms [22], E
BRCA1	DNA	promoter hypermethylation	correlates with	non-familial/sporadic		Breast Neoplasms		hypermethylation of the BRCA1 promoter correlates with non-familial form of breast neoplasms [30], E
BRCA1	DNA	gene deletion mutation	may cause	increased occurrence of familial form		Breast Neoplasms		deletion mutation in the BRCA1 gene may cause increased occurrence of familial form of breast neoplasms [51], E; [23], E
BRCA1	DNA	gene deletion mutation	may cause		transcription	Breast Neoplasms		deletion mutation in the BRCA1 gene may cause abnormal transcription associated with breast neoplasms [34], E
BRCA1	Protein	ubiquitin-protein ligase activity	may cause		protein polyubiquitination	Breast Neoplasms		absence of the ubiquitin-protein ligase activity of BRCA1 may cause decreased protein polyubiquitination associated with breast neoplasms [26], E
BRCA1	Protein	increased protein expression	correlates with		response to drug	Breast Neoplasms		increased expression of BRCA1 protein correlates with increased response to drug associated with breast neoplasms [37], E
BRCA1	Protein	decreased folding	may cause			Breast Neoplasms		decreased folding of BRCA1 may cause breast neoplasms [8], E
BRCA1	DNA	mutation in PFAM domain	causes			Breast Neoplasms		mutation in the BRCA1 C Terminus (BRCT) domain of BRCA1 causes breast neoplasms [11], E
BRCA1	DNA	gene mutation	correlates with		DNA repair	Breast Neoplasms		mutation in the BRCA1 gene correlates with decreased DNA repair associated with breast neoplasms [17], E
BRCA1	DNA	gene loss of heterozygosity	correlates with	Carcinoma, Small Cell		Breast Neoplasms		loss of heterozygosity at the BRCA1 gene correlates with small cell carcinoma associated with breast neoplasms [18], E
BRCA1	DNA	gene mutation	correlates with		protein metabolic process	Breast Neoplasms		mutation in the BRCA1 gene correlates with abnormal protein metabolic process associated with breast neoplasms [12], E
BRCA1	DNA	gene mutation	causes	increased occurrence of early onset form		Breast Neoplasms		mutation in the BRCA1 gene causes increased occurrence of early onset form of breast neoplasms [43], E; [9], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms		mutation in the BRCA1 gene correlates with breast neoplasms [16], E
BRCA1	DNA	gene mutation	correlates with	early onset		Breast Neoplasms		mutation in the BRCA1 gene correlates with early onset form of breast neoplasms [28], E
BRCA1	mRNA	increased mRNA expression	may correlate with		response to organic substance	Breast Neoplasms		increased expression of BRCA1 mRNA may correlate with increased response to organic substance associated with breast neoplasms [6], E
BRCA1	mRNA	lack of mRNA expression	correlates with	non-familial/sporadic		Breast Neoplasms		lack of expression of BRCA1 mRNA correlates with non-familial form of breast neoplasms [30], E
BRCA1	Protein	transcription activator activity	may cause	increased occurrence of familial form		Breast Neoplasms		decreased transcription activator activity of BRCA1 may cause increased occurrence of familial form of breast neoplasms [23], E
BRCA1	DNA	promoter hypermethylation	may cause			Breast Neoplasms		hypermethylation of the BRCA1 promoter may cause breast neoplasms [35], E
BRCA1	DNA	gene mutation	correlates with	familial		Breast Neoplasms		mutation in the BRCA1 gene correlates with familial form of breast neoplasms [12], E; [41], E; [28], E
BRCA1	DNA	gene mutation	may cause	increased occurrence of familial form		Breast Neoplasms		mutation in the BRCA1 gene may cause increased occurrence of familial form of breast neoplasms [14], E
BRCA1	DNA	gene deletion mutation	may cause		chromatin remodeling	Breast Neoplasms		deletion mutation in the BRCA1 gene may cause abnormal chromatin remodeling associated with breast neoplasms [34], E
BRCA1	DNA	gene missense mutation	may cause	increased occurrence of familial form		Breast Neoplasms		missense mutation in the BRCA1 gene may cause increased occurrence of familial form of breast neoplasms [51], E; [23], E
BRCA1	DNA	promoter hypermethylation	correlates with			Breast Neoplasms		hypermethylation of the BRCA1 promoter correlates with carcinoma tumors associated with breast neoplasms [30], E
BRCA1	DNA	gene mutation	causes	familial		Breast Neoplasms		mutation in the BRCA1 gene causes familial form of breast neoplasms [53], E
BRCA1	mRNA	lack of mRNA expression	correlates with			Breast Neoplasms		lack of expression of BRCA1 mRNA correlates with carcinoma tumors associated with breast neoplasms [30], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms		mutation in the BRCA1 gene correlates with carcinoma tumors associated with breast neoplasms [41], E
BRCA1	DNA	gene mutation	correlates with	Disease Susceptibility		Breast Neoplasms		mutation in the BRCA1 gene correlates with increased occurrence of disease susceptibility associated with breast neoplasms [13], E
BRCA1	Protein	altered protein stability	may cause			Breast Neoplasms		abnormal stability of BRCA1 may cause breast neoplasms [11], E
BRCA1	DNA	gene mutation	may cause		protein polyubiquitination	Breast Neoplasms		mutation in the BRCA1 gene may cause decreased protein polyubiquitination associated with breast neoplasms [26], E
BRCA1	DNA	promoter hypermethylation	may cause	non-familial/sporadic		Breast Neoplasms		hypermethylation of the BRCA1 promoter may cause non-familial form of breast neoplasms [35], E
BRCA1	Protein	lack of protein expression	correlates with	Death		Breast Neoplasms		lack of expression of BRCA1 protein correlates with increased occurrence of death associated with breast neoplasms [25], E
BRCA1	DNA	gene nonsense mutation	may cause	increased occurrence of familial form		Breast Neoplasms		nonsense mutation in the BRCA1 gene may cause increased occurrence of familial form of breast neoplasms [51], E; [23], E
BRCA1	Protein	increased protein expression	correlates with		cell proliferation	Breast Neoplasms		increased expression of BRCA1 protein correlates with decreased cell proliferation associated with breast neoplasms [37], E
BRCA1	DNA	gene mutation	may cause		DNA repair	Breast Neoplasms		mutation in the BRCA1 gene may cause decreased DNA repair associated with breast neoplasms [10], E
BRCA1	DNA	gene insertion mutation	may cause	increased occurrence of familial form		Breast Neoplasms		insertion mutation in the BRCA1 gene may cause increased occurrence of familial form of breast neoplasms [51], E
BRCA1	DNA	gene mutation	correlates with		transcription	Breast Neoplasms		mutation in the BRCA1 gene correlates with abnormal transcription associated with breast neoplasms [15], E
BRCA1	DNA	protein domain missense mutation	causes			Breast Neoplasms		missense mutation in the BRCA1 C Terminus (BRCT) domain of BRCA1 causes breast neoplasms [8], E
BRCA1	Protein	decreased protein stability	may cause			Breast Neoplasms		decreased stability of BRCA1 may cause breast neoplasms [8], E
BRCA1	DNA	gene mutation	may cause		transcription	Breast Neoplasms		mutation in the BRCA1 gene may cause abnormal transcription associated with breast neoplasms [21], E
BRCA1	DNA	gene missense mutation	may correlate with	Prostatic Neoplasms		Breast Neoplasms, Male		missense mutation in the BRCA1 gene may correlate with prostatic neoplasms associated with male breast neoplasms [4], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms, Male		mutation in the BRCA1 gene correlates with male breast neoplasms [16], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Carcinoma, Non-Small-Cell Lung		hypermethylation of the BRCA1 promoter may correlate with non-small-cell lung carcinoma [2], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Carcinoma, Non-Small-Cell Lung		hypermethylation of the BRCA1 promoter may correlate with adenocarcinoma tumors associated with non-small-cell lung carcinoma [2], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Colonic Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with colonic neoplasms [49], E
BRCA1	DNA	gene mutation	may correlate with	Disease Susceptibility		Colorectal Neoplasms		mutation in the BRCA1 gene may correlate with increased occurrence of disease susceptibility associated with colorectal neoplasms [32], E
BRCA1	DNA	gene mutation	may correlate with	increased occurrence of non-familial form		Colorectal Neoplasms		mutation in the BRCA1 gene may correlate with increased occurrence of non-familial form of colorectal neoplasms [32], E
BRCA1	DNA	gene insertion mutation	may not cause	Disease Susceptibility		Colorectal Neoplasms		insertion mutation in the BRCA1 gene does not cause increased occurrence of disease susceptibility associated with colorectal neoplasms [27], E
BRCA1	Protein	increased protein expression	correlates with			Colorectal Neoplasms		increased expression of BRCA1 protein correlates with carcinoma tumors associated with colorectal neoplasms [20], E
BRCA1	DNA	gene mutation	does not correlate with	Disease Susceptibility		Colorectal Neoplasms		mutation in the BRCA1 gene does not correlate with increased occurrence of disease susceptibility associated with colorectal neoplasms [33], E
BRCA1	DNA	gene deletion mutation	may not cause	Disease Susceptibility		Colorectal Neoplasms		deletion mutation in the BRCA1 gene does not cause increased occurrence of disease susceptibility associated with colorectal neoplasms [27], E
BRCA1	Protein	increased protein localization	correlates with			Colorectal Neoplasms		increased nucleus localization of BRCA1 correlates with carcinoma tumors associated with colorectal neoplasms [20], E
BRCA1	Protein	increased protein localization	correlates with	non-familial/sporadic		Colorectal Neoplasms		increased nucleus localization of BRCA1 correlates with non-familial form of colorectal neoplasms [20], E
BRCA1	Protein	increased protein expression	correlates with	non-familial/sporadic		Colorectal Neoplasms		increased expression of BRCA1 protein correlates with non-familial form of colorectal neoplasms [20], E
BRCA1	DNA	locus loss of heterozygosity	correlates with	Barrett Esophagus		Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with Barrett esophagus associated with esophageal neoplasms [42], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with adenocarcinoma tumors associated with esophageal neoplasms [42], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with squamous cell carcinoma tumors associated with esophageal neoplasms [52], E
BRCA1	DNA	gene polymorphism	may correlate with			Eye Diseases, Hereditary		polymorphism in the BRCA1 gene may correlate with melanoma tumors associated with hereditary eye diseases [47], E
BRCA1	DNA	locus loss of heterozygosity	may correlate with			Laryngeal Neoplasms		loss of heterozygosity at the BRCA1 locus may correlate with laryngeal neoplasms [50], E
BRCA1	DNA	gene polymorphism	may correlate with			Melanoma		polymorphism in the BRCA1 gene may correlate with melanoma [47], E
BRCA1	mRNA	decreased mRNA expression	correlates with	invasive		Melanoma		decreased expression of BRCA1 mRNA correlates with invasive form of melanoma [1], E
BRCA1	mRNA	decreased mRNA expression	correlates with			Melanoma		decreased expression of BRCA1 mRNA correlates with melanoma [1], E
BRCA1	DNA	promoter hypermethylation	correlates with			Ovarian Neoplasms		hypermethylation of the BRCA1 promoter correlates with carcinoma tumors associated with ovarian neoplasms [30], E
BRCA1	DNA	gene deletion mutation	may cause	increased occurrence of familial form		Ovarian Neoplasms		deletion mutation in the BRCA1 gene may cause increased occurrence of familial form of ovarian neoplasms [23], E
BRCA1	mRNA	increased mRNA expression	correlates with			Ovarian Neoplasms		increased expression of BRCA1 mRNA correlates with ovarian neoplasms [39], E
BRCA1	DNA	promoter hypermethylation	may cause	non-familial/sporadic		Ovarian Neoplasms		hypermethylation of the BRCA1 promoter may cause non-familial form of ovarian neoplasms [35], E
BRCA1	DNA	promoter hypermethylation	correlates with	non-familial/sporadic		Ovarian Neoplasms		hypermethylation of the BRCA1 promoter correlates with non-familial form of ovarian neoplasms [30], E
BRCA1	mRNA	lack of mRNA expression	correlates with	non-familial/sporadic		Ovarian Neoplasms		lack of expression of BRCA1 mRNA correlates with non-familial form of ovarian neoplasms [30], E
BRCA1	DNA	gene mutation	causes	familial		Ovarian Neoplasms		mutation in the BRCA1 gene causes familial form of ovarian neoplasms [53], E
BRCA1	DNA	gene nonsense mutation	may cause	increased occurrence of familial form		Ovarian Neoplasms		nonsense mutation in the BRCA1 gene may cause increased occurrence of familial form of ovarian neoplasms [23], E
BRCA1	Protein	transcription activator activity	may cause	increased occurrence of familial form		Ovarian Neoplasms		decreased transcription activator activity of BRCA1 may cause increased occurrence of familial form of ovarian neoplasms [23], E
BRCA1	DNA	gene missense mutation	may cause	increased occurrence of familial form		Ovarian Neoplasms		missense mutation in the BRCA1 gene may cause increased occurrence of familial form of ovarian neoplasms [23], E
BRCA1	DNA	gene mutation	correlates with			Ovarian Neoplasms		mutation in the BRCA1 gene correlates with ovarian neoplasms [16], E
BRCA1	DNA	gene mutation	correlates with	familial		Ovarian Neoplasms		mutation in the BRCA1 gene correlates with familial form of ovarian neoplasms [41], E
BRCA1	DNA	promoter hypermethylation	may cause			Ovarian Neoplasms		hypermethylation of the BRCA1 promoter may cause ovarian neoplasms [35], E
BRCA1	mRNA	lack of mRNA expression	correlates with			Ovarian Neoplasms		lack of expression of BRCA1 mRNA correlates with carcinoma tumors associated with ovarian neoplasms [30], E
BRCA1	DNA	gene mutation	correlates with			Ovarian Neoplasms		mutation in the BRCA1 gene correlates with carcinoma tumors associated with ovarian neoplasms [41], E
BRCA1	mRNA	decreased mRNA expression	correlates with	Adenocarcinoma		Pancreatic Neoplasms		decreased expression of BRCA1 mRNA correlates with adenocarcinoma associated with pancreatic neoplasms [5], E
BRCA1	mRNA	decreased mRNA expression	correlates with	Death		Pancreatic Neoplasms		decreased expression of BRCA1 mRNA correlates with increased occurrence of death associated with pancreatic neoplasms [5], E
BRCA1	DNA	gene insertion mutation	may correlate with			Pancreatic Neoplasms		insertion mutation in the BRCA1 gene may correlate with adenocarcinoma tumors associated with pancreatic neoplasms [31], E
BRCA1	DNA	gene insertion mutation	may correlate with	familial		Pancreatic Neoplasms		insertion mutation in the BRCA1 gene may correlate with familial form of pancreatic neoplasms [31], E
BRCA1	mRNA	decreased mRNA expression	correlates with	chronic		Pancreatitis, Alcoholic		decreased expression of BRCA1 mRNA correlates with chronic form of alcoholic pancreatitis [5], E
BRCA1	DNA	maps to disease locus	does not correlate with	Genetic Predisposition to Disease		Prostatic Neoplasms		BRCA1 map position does not correlate with genetic predisposition to disease associated with prostatic neoplasms [45], E
BRCA1	DNA	gene mutation	does not correlate with	familial		Prostatic Neoplasms		mutation in the BRCA1 gene does not correlate with familial form of prostatic neoplasms [46], E
BRCA1	DNA	gene mutation	may not correlate with	early onset		Prostatic Neoplasms		mutation in the BRCA1 gene may not correlate with early onset form of prostatic neoplasms [29], E
BRCA1	Protein	transcription coactivator activity	may cause		cell death	Prostatic Neoplasms		increased transcription coactivator activity of BRCA1 may cause increased cell death associated with prostatic neoplasms [36], E
BRCA1	mRNA	increased mRNA expression	may correlate with	Aneuploidy		Prostatic Neoplasms		increased expression of BRCA1 mRNA may correlate with aneuploidy associated with prostatic neoplasms [19], E
BRCA1	Protein	increased protein expression	may cause		cell proliferation	Prostatic Neoplasms		increased expression of BRCA1 protein may cause increased cell proliferation associated with prostatic neoplasms [24], E
BRCA1	Protein	increased protein expression	correlates with		cell proliferation	Prostatic Neoplasms		increased expression of BRCA1 protein correlates with decreased cell proliferation associated with prostatic neoplasms [37], E
BRCA1	DNA	gene missense mutation	may correlate with	Breast Neoplasms, Male		Prostatic Neoplasms		missense mutation in the BRCA1 gene may correlate with male breast neoplasms associated with prostatic neoplasms [4], E
BRCA1	DNA	gene mutation	may not correlate with	familial		Prostatic Neoplasms		mutation in the BRCA1 gene may not correlate with familial form of prostatic neoplasms [29], E; [38], E
BRCA1	mRNA	decreased mRNA expression	may correlate with	less severe		Prostatic Neoplasms		decreased expression of BRCA1 mRNA may correlate with less severe form of prostatic neoplasms [40], E
BRCA1	mRNA	increased mRNA expression	correlates with			Prostatic Neoplasms		increased expression of BRCA1 mRNA correlates with prostatic neoplasms [39], E
BRCA1	DNA	maps to disease locus	correlates with	Genetic Predisposition to Disease		Prostatic Neoplasms		BRCA1 map position correlates with genetic predisposition to disease associated with prostatic neoplasms [7], E
BRCA1	Protein	maps to disease locus	correlates with	Neoplasm Metastasis		Prostatic Neoplasms		BRCA1 map position correlates with decreased severity of neoplasm metastasis associated with prostatic neoplasms [48], E
BRCA1	Protein	increased protein expression	correlates with		response to drug	Prostatic Neoplasms		increased expression of BRCA1 protein correlates with increased response to drug associated with prostatic neoplasms [37], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Uterine Cervical Neoplasms		hypermethylation of the BRCA1 promoter may correlate with uterine cervical neoplasms [3], E
BRCA1	mRNA	decreased mRNA expression	may correlate with			Uterine Cervical Neoplasms		decreased expression of BRCA1 mRNA may correlate with uterine cervical neoplasms [3], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Uterine Cervical Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with carcinoma tumors associated with uterine cervical neoplasms [44], E

References [hide]

(53 entries)

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