Property Report: BRCA1

E	Experimentally determined
S	Predicted by sequence similarity
P	Predicted by analysis other than seq. similarity
K	Predicted by BioKnowledge^TM Transfer by BIOBASE
see	Indicates references that mention and cite a finding, but do not demonstrate it directly.

Human BRCA1	Correlative associations for BRCA1

Gene/Protein	Molecule	Alteration	Relationship	Sub-type / Linked disorders	Biological Process	Disease	Tissue Specificity	Annotation & Reference
BRCA1	DNA	promoter hypermethylation	correlates with	non-familial/sporadic		Breast Neoplasms		hypermethylation of the BRCA1 promoter correlates with non-familial form of breast neoplasms [19], E
BRCA1	DNA	gene mutation	correlates with	familial		Breast Neoplasms		mutation in the BRCA1 gene correlates with familial form of breast neoplasms [10], E; [25], E; [17], E
BRCA1	DNA	promoter hypermethylation	correlates with			Breast Neoplasms		hypermethylation of the BRCA1 promoter correlates with carcinoma tumors associated with breast neoplasms [19], E
BRCA1	Protein	increased protein expression	correlates with		response to drug	Breast Neoplasms		increased expression of BRCA1 protein correlates with increased response to drug associated with breast neoplasms [18], E
BRCA1	mRNA	lack of mRNA expression	correlates with			Breast Neoplasms		lack of expression of BRCA1 mRNA correlates with carcinoma tumors associated with breast neoplasms [19], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms		mutation in the BRCA1 gene correlates with carcinoma tumors associated with breast neoplasms [25], E
BRCA1	DNA	gene mutation	correlates with	Disease Susceptibility		Breast Neoplasms		mutation in the BRCA1 gene correlates with increased occurrence of disease susceptibility associated with breast neoplasms [11], E
BRCA1	DNA	gene mutation	correlates with		DNA repair	Breast Neoplasms		mutation in the BRCA1 gene correlates with decreased DNA repair associated with breast neoplasms [12], E
BRCA1	DNA	gene loss of heterozygosity	correlates with	Carcinoma, Small Cell		Breast Neoplasms		loss of heterozygosity at the BRCA1 gene correlates with small cell carcinoma associated with breast neoplasms [13], E
BRCA1	DNA	gene mutation	correlates with		protein metabolic process	Breast Neoplasms		mutation in the BRCA1 gene correlates with abnormal protein metabolic process associated with breast neoplasms [10], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms		mutation in the BRCA1 gene correlates with breast neoplasms [9], E
BRCA1	Protein	lack of protein expression	correlates with	Death		Breast Neoplasms		lack of expression of BRCA1 protein correlates with increased occurrence of death associated with breast neoplasms [15], E
BRCA1	Protein	increased protein expression	correlates with		cell proliferation	Breast Neoplasms		increased expression of BRCA1 protein correlates with decreased cell proliferation associated with breast neoplasms [18], E
BRCA1	DNA	gene mutation	correlates with	early onset		Breast Neoplasms		mutation in the BRCA1 gene correlates with early onset form of breast neoplasms [17], E
BRCA1	mRNA	increased mRNA expression	may correlate with		response to organic substance	Breast Neoplasms		increased expression of BRCA1 mRNA may correlate with increased response to organic substance associated with breast neoplasms [6], E
BRCA1	mRNA	lack of mRNA expression	correlates with	non-familial/sporadic		Breast Neoplasms		lack of expression of BRCA1 mRNA correlates with non-familial form of breast neoplasms [19], E
BRCA1	DNA	gene mutation	correlates with		transcription	Breast Neoplasms		mutation in the BRCA1 gene correlates with abnormal transcription associated with breast neoplasms [8], E
BRCA1	DNA	gene missense mutation	may correlate with	Prostatic Neoplasms		Breast Neoplasms, Male		missense mutation in the BRCA1 gene may correlate with prostatic neoplasms associated with male breast neoplasms [1], E
BRCA1	DNA	gene mutation	correlates with			Breast Neoplasms, Male		mutation in the BRCA1 gene correlates with male breast neoplasms [9], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Carcinoma, Non-Small-Cell Lung		hypermethylation of the BRCA1 promoter may correlate with non-small-cell lung carcinoma [3], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Carcinoma, Non-Small-Cell Lung		hypermethylation of the BRCA1 promoter may correlate with adenocarcinoma tumors associated with non-small-cell lung carcinoma [3], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Colonic Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with colonic neoplasms [29], E
BRCA1	DNA	gene mutation	may correlate with	Disease Susceptibility		Colorectal Neoplasms		mutation in the BRCA1 gene may correlate with increased occurrence of disease susceptibility associated with colorectal neoplasms [21], E
BRCA1	DNA	gene mutation	may correlate with	increased occurrence of non-familial form		Colorectal Neoplasms		mutation in the BRCA1 gene may correlate with increased occurrence of non-familial form of colorectal neoplasms [21], E
BRCA1	Protein	increased protein expression	correlates with			Colorectal Neoplasms		increased expression of BRCA1 protein correlates with carcinoma tumors associated with colorectal neoplasms [16], E
BRCA1	Protein	increased protein localization	correlates with			Colorectal Neoplasms		increased nucleus localization of BRCA1 correlates with carcinoma tumors associated with colorectal neoplasms [16], E
BRCA1	Protein	increased protein localization	correlates with	non-familial/sporadic		Colorectal Neoplasms		increased nucleus localization of BRCA1 correlates with non-familial form of colorectal neoplasms [16], E
BRCA1	Protein	increased protein expression	correlates with	non-familial/sporadic		Colorectal Neoplasms		increased expression of BRCA1 protein correlates with non-familial form of colorectal neoplasms [16], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with adenocarcinoma tumors associated with esophageal neoplasms [27], E
BRCA1	DNA	locus loss of heterozygosity	correlates with	Barrett Esophagus		Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with Barrett esophagus associated with esophageal neoplasms [27], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Esophageal Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with squamous cell carcinoma tumors associated with esophageal neoplasms [31], E
BRCA1	DNA	gene polymorphism	may correlate with			Eye Diseases, Hereditary		polymorphism in the BRCA1 gene may correlate with melanoma tumors associated with hereditary eye diseases [26], E
BRCA1	DNA	locus loss of heterozygosity	may correlate with			Laryngeal Neoplasms		loss of heterozygosity at the BRCA1 locus may correlate with laryngeal neoplasms [30], E
BRCA1	DNA	gene polymorphism	may correlate with			Melanoma		polymorphism in the BRCA1 gene may correlate with melanoma [26], E
BRCA1	mRNA	decreased mRNA expression	correlates with	invasive		Melanoma		decreased expression of BRCA1 mRNA correlates with invasive form of melanoma [2], E
BRCA1	mRNA	decreased mRNA expression	correlates with			Melanoma		decreased expression of BRCA1 mRNA correlates with melanoma [2], E
BRCA1	DNA	promoter hypermethylation	correlates with			Ovarian Neoplasms		hypermethylation of the BRCA1 promoter correlates with carcinoma tumors associated with ovarian neoplasms [19], E
BRCA1	DNA	gene mutation	correlates with			Ovarian Neoplasms		mutation in the BRCA1 gene correlates with ovarian neoplasms [9], E
BRCA1	DNA	gene mutation	correlates with	familial		Ovarian Neoplasms		mutation in the BRCA1 gene correlates with familial form of ovarian neoplasms [25], E
BRCA1	mRNA	increased mRNA expression	correlates with			Ovarian Neoplasms		increased expression of BRCA1 mRNA correlates with ovarian neoplasms [22], E
BRCA1	DNA	promoter hypermethylation	correlates with	non-familial/sporadic		Ovarian Neoplasms		hypermethylation of the BRCA1 promoter correlates with non-familial form of ovarian neoplasms [19], E
BRCA1	mRNA	lack of mRNA expression	correlates with	non-familial/sporadic		Ovarian Neoplasms		lack of expression of BRCA1 mRNA correlates with non-familial form of ovarian neoplasms [19], E
BRCA1	mRNA	lack of mRNA expression	correlates with			Ovarian Neoplasms		lack of expression of BRCA1 mRNA correlates with carcinoma tumors associated with ovarian neoplasms [19], E
BRCA1	DNA	gene mutation	correlates with			Ovarian Neoplasms		mutation in the BRCA1 gene correlates with carcinoma tumors associated with ovarian neoplasms [25], E
BRCA1	DNA	gene insertion mutation	may correlate with			Pancreatic Neoplasms		insertion mutation in the BRCA1 gene may correlate with adenocarcinoma tumors associated with pancreatic neoplasms [20], E
BRCA1	mRNA	decreased mRNA expression	correlates with	Adenocarcinoma		Pancreatic Neoplasms		decreased expression of BRCA1 mRNA correlates with adenocarcinoma associated with pancreatic neoplasms [4], E
BRCA1	DNA	gene insertion mutation	may correlate with	familial		Pancreatic Neoplasms		insertion mutation in the BRCA1 gene may correlate with familial form of pancreatic neoplasms [20], E
BRCA1	mRNA	decreased mRNA expression	correlates with	Death		Pancreatic Neoplasms		decreased expression of BRCA1 mRNA correlates with increased occurrence of death associated with pancreatic neoplasms [4], E
BRCA1	mRNA	decreased mRNA expression	correlates with	chronic		Pancreatitis, Alcoholic		decreased expression of BRCA1 mRNA correlates with chronic form of alcoholic pancreatitis [4], E
BRCA1	Protein	increased protein expression	correlates with		cell proliferation	Prostatic Neoplasms		increased expression of BRCA1 protein correlates with decreased cell proliferation associated with prostatic neoplasms [18], E
BRCA1	DNA	gene missense mutation	may correlate with	Breast Neoplasms, Male		Prostatic Neoplasms		missense mutation in the BRCA1 gene may correlate with male breast neoplasms associated with prostatic neoplasms [1], E
BRCA1	mRNA	decreased mRNA expression	may correlate with	less severe		Prostatic Neoplasms		decreased expression of BRCA1 mRNA may correlate with less severe form of prostatic neoplasms [24], E
BRCA1	mRNA	increased mRNA expression	correlates with			Prostatic Neoplasms		increased expression of BRCA1 mRNA correlates with prostatic neoplasms [22], E
BRCA1	DNA	maps to disease locus	correlates with	Genetic Predisposition to Disease		Prostatic Neoplasms		BRCA1 map position correlates with genetic predisposition to disease associated with prostatic neoplasms [7], E
BRCA1	mRNA	increased mRNA expression	may correlate with	Aneuploidy		Prostatic Neoplasms		increased expression of BRCA1 mRNA may correlate with aneuploidy associated with prostatic neoplasms [14], E
BRCA1	Protein	increased protein expression	correlates with		response to drug	Prostatic Neoplasms		increased expression of BRCA1 protein correlates with increased response to drug associated with prostatic neoplasms [18], E
BRCA1	Protein	maps to disease locus	correlates with	Neoplasm Metastasis		Prostatic Neoplasms		BRCA1 map position correlates with decreased severity of neoplasm metastasis associated with prostatic neoplasms [28], E
BRCA1	DNA	promoter hypermethylation	may correlate with			Uterine Cervical Neoplasms		hypermethylation of the BRCA1 promoter may correlate with uterine cervical neoplasms [5], E
BRCA1	mRNA	decreased mRNA expression	may correlate with			Uterine Cervical Neoplasms		decreased expression of BRCA1 mRNA may correlate with uterine cervical neoplasms [5], E
BRCA1	DNA	locus loss of heterozygosity	correlates with			Uterine Cervical Neoplasms		loss of heterozygosity at the BRCA1 locus correlates with carcinoma tumors associated with uterine cervical neoplasms [23], E

References [hide]

(31 entries)

[1] PMID 15154626 . Male breast adenocarcinoma in a prostate cancer patient following prolonged anti-androgen monotherapy. Anticancer Research 24(2) 1077-81 (2004)

[2] PMID 15009718 . Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression. J Invest Dermatol 122(2) 369-80 (2004)

[3] PMID 14647419 . Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23(4) 1000-4 (2004)

[4] PMID 15173085 . Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. Clin Cancer Res 10(11) 3780-7 (2004)

[5] PMID 15126331 . Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer. Cancer Research 64(9) 2994-7 (2004)

[1] PMID 15154626 . Male breast adenocarcinoma in a prostate cancer patient following prolonged anti-androgen monotherapy. Anticancer Research 24(2) 1077-81 (2004)

[2] PMID 15009718 . Downregulation of BRCA1 in A375 melanoma cell line increases radio-sensitivity and modifies metastatic and angiogenic gene expression. J Invest Dermatol 122(2) 369-80 (2004)

[3] PMID 14647419 . Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23(4) 1000-4 (2004)

[4] PMID 15173085 . Down-regulation of BRCA1 in chronic pancreatitis and sporadic pancreatic adenocarcinoma. Clin Cancer Res 10(11) 3780-7 (2004)

[5] PMID 15126331 . Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer. Cancer Research 64(9) 2994-7 (2004)

[6] PMID 12838319 . Resveratrol increases BRCA1 and BRCA2 mRNA expression in breast tumour cell lines. British Journal Of Cancer 89(1) 168-72. (2003)

[7] PMID 14601029 . Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. Prostate 57(4) 326-34 (2003)

[8] PMID 11823860 . Gene expression profiling predicts clinical outcome of breast cancer. Nature 415(6871) 530-6. (2002)

[9] PMID 11896095 . Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J Clin Oncol 20(6) 1480-90. (2002)

[10] PMID 11981002 . The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2. J Clin Oncol 20(9) 2310-8. (2002)

[11] PMID 11927492 . Variation in BRCA1 cancer risks by mutation position. Cancer Epidemiol Biomarkers Prev 11(4) 329-36. (2002)

[12] PMID 11358831 . TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution. Cancer Research 61(10) 4092-7. (2001)

[13] PMID 11486176 . Primary mammary small-cell carcinoma: a molecular analysis of 2 cases. Hum Pathol 32(7) 753-7. (2001)

[14] PMID 11719443 . The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Research 61(22) 8143-9. (2001)

[15] PMID 11443609 . Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas. Cancer 92(1) 54-60. (2001)

[16] PMID 11497291 . Localization of human BRCA1 and BRCA2 in non-inherited colorectal carcinomas and matched normal mucosas. Anticancer Research 21 2011-20. (2001)

[17] PMID 11504767 . Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. Journal Of The National Cancer Institute 93(16) 1215-23. (2001)

[18] PMID 11042697 . The anti-proliferative effects of 1alpha,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression. Oncogene 19(44) 5091-7 (2000)

[19] PMID 10749912 . Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. Journal Of The National Cancer Institute 92(7) 564-9. (2000)

[20] PMID 10667595 . Inherited predisposition to pancreatic adenocarcinoma: role of family history and germ-line p16, BRCA1, and BRCA2 mutations. Cancer Research 60(2) 409-16 (2000)

[21] PMID 10769725 . Incidence of BRCA1 and BRCA2 mutations in Ashkenazi colorectal cancer patients: preliminary study. Anticancer Research 20 559-61. (2000)

[22] PMID 10972993 . Altered expression of BRCA1, BRCA2, and a newly identified BRCA2 exon 12 deletion variant in malignant human ovarian, prostate, and breast cancer cell lines. Molecular Carcinogenesis 28(4) 236-46 (2000)

[23] PMID 10491526 . Different profiles of allelic losses in cervical carcinoma cases in Surinam and The Netherlands. Cancer 86(6) 997-1004 (1999)

[24] PMID 10344722 . Coordinate alterations in the expression of BRCA1, BRCA2, p300, and Rad51 in response to genotoxic and other stresses in human prostate cancer cells. Prostate 40(1) 37-49 (1999)

[25] PMID 10630170 . Clinical impact of molecular genetic diagnosis, genetic counseling, and management of hereditary cancer. Part I: Studies of cancer in families. Cancer 86(11) 2449-56. (1999)

[26] PMID 10399947 . Germline brca2 sequence variants in patients with ocular melanoma. International Journal Of Cancer 82(3) 325-8 (1999)

[27] PMID 10023674 . Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. Oncogene 18(4) 987-93 (1999)

[28] PMID 9810006 . Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. Cancer Research 58(21) 4963-9 (1998)

[29] PMID 9666805 . Loss of heterozygosity in the region including the BRCA1 gene on 17q in colon cancer. Cancer Genet Cytogenet 104(2) 119-23. (1998)

[30] PMID 7585472 . Loss of heterozygosity at 9p and 17q in human laryngeal tumors. Cancer Letters 97(1) 129-34 (1995)

[31] PMID 7907942 . Frequent loss of heterozygosity in the region including BRCA1 on chromosome 17q in squamous cell carcinomas of the esophagus. Cancer Research 54(7) 1638-40 (1994)

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