Property Report: BRCA1

E	Experimentally determined
S	Predicted by sequence similarity
P	Predicted by analysis other than seq. similarity
K	Predicted by BioKnowledge^TM Transfer by BIOBASE
see	Indicates references that mention and cite a finding, but do not demonstrate it directly.

Human BRCA1	Negative associations for BRCA1

Gene/Protein	Molecule	Alteration	Relationship	Sub-type / Linked disorders	Biological Process	Disease	Tissue Specificity	Annotation & Reference
BRCA1	DNA	gene mutation	does not correlate with	Disease Susceptibility		Colorectal Neoplasms		mutation in the BRCA1 gene does not correlate with increased occurrence of disease susceptibility associated with colorectal neoplasms [2], E
BRCA1	DNA	gene insertion mutation	may not cause	Disease Susceptibility		Colorectal Neoplasms		insertion mutation in the BRCA1 gene does not cause increased occurrence of disease susceptibility associated with colorectal neoplasms [1], E
BRCA1	DNA	gene deletion mutation	may not cause	Disease Susceptibility		Colorectal Neoplasms		deletion mutation in the BRCA1 gene does not cause increased occurrence of disease susceptibility associated with colorectal neoplasms [1], E
BRCA1	DNA	gene mutation	may not correlate with	familial		Prostatic Neoplasms		mutation in the BRCA1 gene may not correlate with familial form of prostatic neoplasms [3], E; [4], E
BRCA1	DNA	maps to disease locus	does not correlate with	Genetic Predisposition to Disease		Prostatic Neoplasms		BRCA1 map position does not correlate with genetic predisposition to disease associated with prostatic neoplasms [5], E
BRCA1	DNA	gene mutation	does not correlate with	familial		Prostatic Neoplasms		mutation in the BRCA1 gene does not correlate with familial form of prostatic neoplasms [6], E
BRCA1	DNA	gene mutation	may not correlate with	early onset		Prostatic Neoplasms		mutation in the BRCA1 gene may not correlate with early onset form of prostatic neoplasms [3], E

References [hide]

(6 entries)

[1] PMID 11207040 . The frequency of the predominant Jewish mutations in BRCA1 and BRCA2 in unselected Ashkenazi colorectal cancer patients. British Journal Of Cancer 84(4) 475-7. (2001)

[2] PMID 11072248 . Genetic analysis of a breast-ovarian cancer family, with 7 cases of colorectal cancer linked to BRCA1, fails to support a role for BRCA1 in colorectal tumorigenesis. International Journal Of Cancer 88(5) 778-82. (2000)

[3] PMID 10945492 . The rate of the founder Jewish mutations in BRCA1 and BRCA2 in prostate cancer patients in Israel. British Journal Of Cancer 83(4) 463-6 (2000)

[4] PMID 10728701 . BRCA1 and BRCA2 have a limited role in familial prostate cancer. Cancer Research 60(5) 1371-5 (2000)

[5] PMID 10398279 . Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men. Prostate 40(3) 172-7 (1999)

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