Property Report
E Experimentally determined
S Predicted by sequence similarity
P Predicted by analysis other than seq. similarity
K Predicted by BioKnowledgeTM Transfer by BIOBASE
see Indicates references that mention and cite a finding, but do not demonstrate it directly.
Legend: upregulates Upregulates ...downregulates Downregulates ... no effectDoes not affect ... ... the following genes
Human BRCA1 Regulates Expression of

  • BCL2(h)
    • Up
    upregulates     		[1]

  • CCNB1(h)
    • Down
    downregulates     		[12]

  • CDKN1A(h)
    • Up
    upregulates     		[13]

  • CYP1A1(h)
    • No
    no effect     		[5]

  • DDIT3(h)
    • Up
    upregulates     		[12]

  • DPH1(h)
    • Up
    upregulates     		[9]

  • ERBB2IP(h)
    • Up
    upregulates     		[9]

  • ESR1(h)
    • Up
    upregulates     		[1]

  • GADD45A(h)
    • Up
    upregulates     		[14; 15]

  • HSPB1(h)
    • Up
    upregulates     		[4]

  • IGF1R(h)
    • Down
    downregulates     		[3]

  • IRF7(h)
    • Up
    upregulates     		[6]

  • MSH2(h)
    • Up
    upregulates     		[9]

  • MX1(h)
    • Up
    upregulates     		[6]

  • PLK1(h)
    • Down
    downregulates     		[2]

  • RAD21(h)
    • Up
    upregulates     		[9]

  • TERT(h)
    • Down
    downregulates     		[8]

  • TNF(h)
    • Up
    upregulates     		[11]

  • VEGFA(h)
    • Down
    downregulates     		[10]

  • WEE1(h)
    • Up
    upregulates     		[7]
    [less]
    References  [hide]    (15 entries)
    jump to top
    [1] PMID 12682913. BRCA1 splice variants exhibit overlapping and distinct transcriptional transactivation activities. Journal Of Cellular Biochemistry 89(1) 120-32. (2003)
    [2] PMID 14654792. Repression of mRNA for the PLK cell cycle gene after DNA damage requires BRCA1. Oncogene 22(55) 8952-5. (2003)
    [3] PMID 12706836. BRCA1-Sp1 interactions in transcriptional regulation of the IGF-IR gene. Febs Letters 541(1) 149-54 (2003)
    [4] PMID 12527903. Role of BRCA1 in heat shock response. Oncogene 22(1) 10-27. (2003)
    [5] PMID 11782367. Activation of the aromatic hydrocarbon receptor pathway is not sufficient for transcriptional repression of BRCA-1: requirements for metabolism of benzo[a]pyrene to 7r,8t-dihydroxy-9t,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. Cancer Research 62(1) 113-21. (2002)
    [6] PMID 12011077. BRCA1 regulates the interferon gamma-mediated apoptotic response. Journal Of Biological Chemistry 277(29) 26225-32. (2002)
    [7] PMID 11836499. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nature Genetics 30(3) 285-9. (2002)
    [8] PMID 11916966. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. Journal Of Biological Chemistry 277(23) 20965-73. (2002)
    [9] PMID 12470655. Identification of genes induced by BRCA1 in breast cancer cells. Biochemical And Biophysical Research Communications 299(5) 839-46 (2002)
    [10] PMID 12400015. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene 21(50) 7730-9. (2002)
    [11] PMID 10945975. BRCA1 physically and functionally interacts with ATF1. Journal Of Biological Chemistry 275(46) 36230-7 (2000)
    [12] PMID 10644742. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. Journal Of Biological Chemistry 275(4) 2777-85. (2000)
    [13] PMID 10792030. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. Proceedings Of The National Academy Of Sciences Of The United States Of America 97(10) 5208-13 (2000)
    [14] PMID 10910365. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 406(6792) 210-5 (2000)
    [15] PMID 10367887. Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97(5) 575-86 (1999)
    [less]
    Copyright BIOBASE
    All rights reserved. Not for distribution.