The budding yeast Saccharomyces cerevisiae is a model eukaryote that allows for the study of a wide array of basic cellular functions that are conserved throughout higher species including DNA replication, cell-cycle regulation, protein trafficking, respiration, cytoskeleton organization, and transcriptional regulation.

The Yeast Proteome Database (YPD) is a comprehensive knowledge resource for the proteins of S. cerevisiae. The complete S. cerevisiae proteome is connected to unparalleled depth and quality of annotation cited directly from the yeast literature.

Annotation focuses on the molecular function and biological role of proteins, consequences of gene mutation and the physical and regulatory interactions between proteins and genes.

Application of this database to pharmaceutical drug development is enhanced by extensive interconnections to our mammalian databases.