BIOBASE BRENDA Professional is the main collection of enzyme functional data available to the scientific community worldwide.  The enzymes are classified according to the Enzyme Commission list of enzymes.

BRENDA Professional is maintained and developed at the Institute of Biochemistry and Bioinformatics at the Technical University of Braunschweig, Germany. Data on enzyme function are extracted directly from the primary literature by scientists holding a degree in Biology or Chemistry.

The database is built on a relational database of molecular and metabolic information.  It provides researchers of biochemistry and medicine a user-friendly navigation system offering access to a comprehensive summary of enzyme specific data.

BRENDA Professional includes biochemical and molecular information on classification, nomenclature, reaction, specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation, and preparation. The database also provides additional information on ligands, which function as natural or in vitro substrates/products, inhibitors, activating compounds, cofactors, bound metals, and other attributes.

BRENDA Professional includes the supplements FRENDA and AMENDA, extracted from about 20 million PubMed references, not available in the public version.  FRENDA (Full Reference ENzyme DAta)  aims at providing an exhaustive collection of literature references containing organism-specific enzyme information. It currently covers nearly 6 million enzyme/organism/reference combinations (nearly 400,000 enzyme/organism combinations).  AMENDA (Automatic Mining of ENzyme DAta) contains a large amount of enzyme data, covering information on (sub)cellular localizations and source tissues.

BRENDA Professional BRENDA Public
Quick, Full-Advanced Text Search Yes Yes
Substructure and Sequence Search Yes Yes
Taxonomy, Genome, EC and Ontology Explorer Yes Yes
SBML Output Yes No
SOAP Integration Yes No
Relational database download Yes No
FRENDA and AMENDA supplement Yes No
Local installation Yes No
Commercial use Yes No



  • Perform individual database queries based on your targets
  • Access to a human-readable database to find data easier without advanced queries
  • The flexibility to integrate BRENDA’s relational database with your existing in-house data and resources
  • The security and privacy of a local installation behind your firewall
  • BRENDA Ligand provides a search for all included synonyms of a given compound and thus facilitates finding all enzyme-ligand-related information.  The ligand structures are provided in three formats (molfile, InChls, gif-pictures)
  • BRENDA Ligand Substructure Search provides chemical substructure searches for most of the small molecules functioning as ligands, using a molecular editor

Key Features

  • The world’s most comprehensive collection of enzyme information.  See product statistics.
  • Data manually curated by experts
  • Supplemented with text-mining based information in FRENDA and AMENDA
  • Quick, full text and advanced text search
  • Substructure and sequence search
  • Taxonomy Explorer, Genome Explorer, EC Explorer and Ontology Explorer
  • SBML output
  • SOAP web-services

Access Options

Commercial use of BRENDA requires a license.  Download access to BRENDA, inclusion of BRENDA components into other databases, or redistribution of BRENDA content, for academic research or commercial use requires a license.

An online subscription provides access to the BRENDA web interface. Online subscriptions are available at the concurrent user and institution-wide level. All subscription levels require username/password authentication.

A download subscription allows for a download of the complete BRENDA relational database and web interface. A download allows you to query and extract all fields of BRENDA data for integration into your own, or 3rd party, analysis pipelines and tools. However redistribution of, or public access to / display of, the data is not allowed without prior written consent. Relational download subscriptions are only available at the institution-wide level. The MySQL platform is supported.